. The research, presented by student Saba Mohammed Jassim, aimed to assess the clinical utility of maternal serum phosphatin as an early diagnostic biomarker for spontaneous preterm birth (PTB), and to analyze its performance using receiver operating characteristic (ROC) curve analysis. The study focused on its correlation with traditional inflammatory markers such as C-reactive protein (CRP) and white blood cell (WBC) count. The research concluded that women experiencing preterm labor had significantly higher phosphatin levels compared to those experiencing term labor or late pregnancy without labor. This strong correlation suggests that phosphatin is involved in the processes leading to preterm birth. Phosphatin could be a valuable non-invasive biomarker for the early detection of women at risk of PTL, enabling timely interventions. Given its known functions in modulating immunity, phosphatine may not only be an indicator, but also an active factor in causing of preterm labor.